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Invokana

Invokana Causes Life-Threatening Glucose Levels & Amputations

Invokana Causes Life-Threatening Glucose Levels & Amputations

“A large industry-sponsored trial found that Invokana doubled the risk of lower limb amputations compared with those taking a placebo.”

Source: Doctors debate danger of popular diabetes drug after FDA amputation warning

In 2013, a new class of drugs were released into the market for the treatment of Type 2 diabetes.

These SGLT2 (sodium/glucose cotransporter 2) inhibitors work by preventing glucose absorption in the blood, and instead allows the patient to pass glucose out through urination.

Despite initial excitement from the medical community, these drugs, namely Invokana and Invokamet, have life-threatening side effects. Unfortunately, patients have not been warned of the risks.

Many type 2 diabetes patients on Invokana and Invokamet experienced serious and life threatening complications, such as amputations.

After experiencing life-threatening side effects, many patients have sought compensation from the drug manufacturer, Janssen Pharmaceuticals.

DO YOU QUALIFY FOR COMPENSATION?

There is a limited window to pursue help. As settlements for Invokana injuries are now being negotiated, take our 30-second survey to see if you qualify… before it’s too late.

DO YOU QUALIFY FOR COMPENSATION?

There is a limited window to pursue help. As settlements for Invokana injuries are now being negotiated, take our 30-second survey to see if you qualify… before it’s too late.

Invokana Warnings In The News

Doctors debate danger of popular diabetes drug after FDA amputation warning
Many San Diego doctors are taking their patients off of Invokana, a widely used diabetes drug, after a large industry-sponsored trial found it doubled the risk of lower limb amputations compared with those taking a placebo.

With 23.1 million people in the U.S. diagnosed with diabetes, many of them are taking newer drugs to control glucose. But new research involving one of those drugs, Invokana, shows a doubled rate of leg, foot and toe amputations.

Patients are being switched to other medications even though the study’s authors say the drug’s benefits — a reduced risk of cardiovascular events including death, non-fatal heart attacks and non-fatal strokes — outweigh its risk of amputations.

The drug is prescribed for people with Type 2 diabetes. The patients in the trial were already at high risk for heart disease and other diabetes complications including amputations.

While a number of physicians interviewed said they still prescribe the drug to lower their patients’ glucose levels, attitudes among others began to change after the U.S. Food and Drug Administration on May 16 issued what’s called a black box warning about amputations.

It urges patients taking canagliflozin, sold under the brand name Invokana, Invokamet and Invokamet XR, to contact their doctors “right away” if they notice pain or tenderness, sores, ulcers or infections in their legs or feet. About half of the amputations occurring among patients in the trial were of toes, while the rest were across the foot, at the ankle, below the knee and above the knee…

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Johnson & Johnson Drug Prevents Heart Attacks At Cost Of Amputated Toes
Invokana, a diabetes drug made by Johnson & Johnson, decreases the risk of heart attacks and strokes, but also increases the risk of amputation, particularly of toes.

The result is a blow to J&J, and a boost to rivals Eli Lilly and Boehringer Ingelheim, who make a similar drug called Jardiance, which has been shown to reduce the risk of cardiovascular death but does not appear to carry the amputation risk.

The study also deepens the mystery about such drugs, known as sodium-glucose co-transporter 2 (SGLT2) inhibitors, which prevent the kidney from absorbing sugar from the blood. This lowers blood sugar, is good for the kidney, but leads to more urinary tract infections and weakened bones. But scientists are not sure why the drugs would prevent cardiovascular disease, and it’s entirely unclear why one of them would lead to amputations. “It justifies the need to test each medicine,” says Harlan Krumholz, of Yale University.

For every three heart attacks, strokes, or cardiovascular deaths prevented by Invokana, there were two amputations, 71% of them of toes or the lower foot, according to the results of the 10,142-patient study, which was funded by Johnson & Johnson. It is being presented at the annual meeting of the American Diabetes Association tonight, and published by the New England Journal of Medicine.

Heart attacks were far more common than amputations. For every year patients took the drug, there were 31.5 heart attacks, strokes, or cardiovascular deaths per 1,000 patients in the placebo group and 26.9 in the group that took Invokana, a 14% decrease…

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FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid in the blood
The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines canagliflozin, dapagliflozin, and empagliflozin may lead to ketoacidosis, a serious condition where the body produces high levels of blood acids called ketones that may require hospitalization. We are continuing to investigate this safety issue and will determine whether changes are needed in the prescribing information for this class of drugs, called sodium-glucose cotransporter-2 (SGLT2)
inhibitors.

Patients should pay close attention for any signs of ketoacidosis and seek medical attention immediately if they experience symptoms such as difficulty breathing, nausea, vomiting, abdominal pain, confusion, and unusual fatigue or sleepiness. Do not stop or change your diabetes medicines without first talking to your prescriber. Health care professionals should evaluate for the presence of acidosis, including ketoacidosis, in patients experiencing these signs or symptoms; discontinue SGLT2 inhibitors if acidosis is confirmed; and take appropriate measures to correct the acidosis and monitor sugar levels.

SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes. When untreated, type 2 diabetes can lead to serious problems, including blindness, nerve and kidney damage, and heart disease. SGLT2 inhibitors lower blood sugar by causing the kidneys to remove sugar from the body through the urine. These medicines are available as single-ingredient products and also in combination with other diabetes medicines such as metformin (see Table 1 below). The safety and efficacy of SGLT2 inhibitors have not been established in patients with type 1 diabetes, and FDA has not approved them for use in these patients.

A search of the FDA Adverse Event Reporting System (FAERS) database identified 20 cases of acidosis reported as diabetic ketoacidosis (DKA), ketoacidosis, or ketosis in…

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FDA Drug Safety Communication: Interim clinical trial results find increased risk of leg and foot amputations, mostly affecting the toes, with the diabetes medicine canagliflozin (Invokana, Invokamet); FDA to investigate
The U.S. Food and Drug Administration (FDA) is alerting the public about interim safety results from an ongoing clinical trial that found an increase in leg and foot amputations, mostly affecting the toes, in patients treated with the diabetes medicine canagliflozin (Invokana, Invokamet). We have not determined whether canagliflozin increases the risk of leg and foot amputations. We are currently investigating this new safety issue and will update the public when we have more information.

Patients should not stop or change their diabetes medicines without first talking to their health care professional. Doing so can lead to uncontrolled blood sugar levels that can be harmful. Over time, this can cause serious problems, including blindness, nerve and kidney damage, and heart disease. Patients taking canaglifozin should notify their health care professionals right away if they notice any new pain or tenderness, sores or ulcers, or infections in their legs or feet.

Health care professionals should follow the recommendations in the canagliflozin drug labels. Monitor patients for the signs and symptoms described above and advise patients to seek medical advice if they experience them.

Canagliflozin is a prescription medicine used with diet and exercise to lower blood sugar in adults with type 2 diabetes. It belongs to a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors. Canagliflozin lowers blood sugar by causing the kidneys to remove sugar from the body through the urine. It is available as a single-ingredient product under the brand name Invokana and also in combination with the diabetes medicine metformin under the brand name Invokamet…

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Janssen Pharmaceuticals Puts Type 2 Diabetes Patients at Risk

The Food & Drug Administration (FDA) approved Invokana in 2013 and subsequently Invokamet in 2014, specifically for the treatment of type 2 diabetes. These were the first SGLT2 inhibitors on the market. In 2015, the FDA issued a warning to patients and their doctors that SGLT2 inhibitors can lead to DKA (Diabetic ketoacidosis), a potentially fatal condition.

Angry and disillusioned patients are now fighting for legal compensation. After experiencing devastating side effects, these patients and their families deserve more than an apology from Janssen Pharmaceuticals.

Video Thumbnail
Invokana: Everything You Need to Know!

Invokana: Everything You Need to Know

Invokana can cause ketoacidosis and other deadly adverse effects like pancreatitis and even death. This video will walk you through what you should know if you or a loved one took this potentially controversial drug.

Invokana Lawsuits & Settlement Landscape

Cases continue to mount against Janssen Pharmaceuticals for their inadequate testing of SGLT2 inhibitors and the life-threatening consequences of using these drugs. Are you suffering from the consequences of being prescribed Invokana or Invokamet? You might be eligible for settlement funds.

For over 20 years, we’ve served as a guardian for people who need to navigate an industry that doesn’t always have their best interests at heart. We provide the information, resources, and direct connection to reputable legal counsel that people need when their lives and livelihoods are at stake. Big pharmaceutical companies cannot silence the injured—not as long as we’re around.

Our in-house legal counsel, Matthew J. Daher, earned his Bachelor of Arts degree from the University of Utah and his law degree from the University of Missouri – Columbia School of Law. Matt has devoted his entire practice to civil litigation, and has spent his career representing the rights of individuals who have been injured by pharmaceuticals, medical devices, medical malpractice, defective products, and motor vehicle accidents. As in-house counsel for Periscope Group, Matt leads our internal legal team and liaises with our external partners.

DO YOU QUALIFY FOR COMPENSATION?

There is a limited window to pursue help. As settlements for Invokana injuries are now being negotiated, take our 30-second survey to see if you qualify… before it’s too late.

DO YOU QUALIFY FOR COMPENSATION?

There is a limited window to pursue help. As settlements for Invokana injuries are now being negotiated, take our 30-second survey to see if you qualify… before it’s too late.

Invokana Glossary of Key Terms

Invokana or Invokamet
Type 2 diabetes drug belonging to a new class of drug called SGLT2 inhibitors that stops glucose from being reabsorbed in the blood. The drug is associated with life threatening consequences of toxicity in the blood , including coma, death, kidney failure and amputations.

Diabetic Coma
A diabetic coma is a reversible, but life-threatening diabetes complication that causes unconsciousness. If you have diabetes or kidney failure, then dangerously high or low blood sugar can lead to diabetic coma. If left untreated, a diabetic coma can be fatal.

Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) is a serious condition in which the body produces high levels of acid in the blood resulting in ketones. DKA occurs when the body cannot use glucose as fuel because there is not enough insulin to convert that glucose into energy.

Dialysis
Dialysis removes excess waste and water from the blood to prevent them from building up in the body. Once you lose about 85-90% of kidney function, you need dialysis to sustain life.

Glucose
A simple sugar that comes from the food we eat that fuels our cells.

Insulin
A hormone made by your pancreas to turn glucose from the food you eat into energy.

Pancreas
The pancreas is responsible for creating enzymes that help our bodies break down food into energy.

SGLT2 Inhibitors
A class of Type 2 diabetes drugs that stops glucose from being reabsorbed into the blood. This class of drugs inhibits a protein in the kidney called SGLT2 that is responsible for absorbing 90% of the glucose in the kidneys.

Type 2 Diabetes
A lifelong disease that affects the way your body processes food. With Type 2 diabetes your body either does not produce enough insulin, or it is resistant to the insulin you do produce.

Health & Wellness Resources for Invokana

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GET YOUR FREE INVOKANA CASE REVIEW TODAY

Financial settlement funds are available for select patients who have suffered, or are currently suffering from, the life-threatening complications of Invokana and Invokamet. Should you choose to pursue legal action, Periscope Group has a team of experienced, dedicated advocates to guide you through the settlement process. We are here to connect you with the right legal professionals, who know how to take a stand against big pharmaceutical companies.

  • * Submit now to learn if you may be eligible for a cash settlement.

Our in-house legal counsel, Matthew J. Daher, earned his Bachelor of Arts degree from the University of Utah and his law degree from the University of Missouri – Columbia School of Law. Matt has devoted his entire practice to civil litigation, and has spent his career representing the rights of individuals who have been injured by pharmaceuticals, medical devices, medical malpractice, defective products, and motor vehicle accidents. As in-house counsel for Periscope Group, Matt leads our internal legal team and liaises with our external partners.

Free Guide Download

The Step-By-Step Guide To Taking Action

How to File for Financial Settlement After Injury from an Unsafe Drug or Device

Free Guide Download

The Step-By-Step Guide To Taking Action

How to File for Financial Settlement After Injury from an Unsafe Drug or Device

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Periscope Group is not owned by or operated on behalf of any attorney or law firm. We are not affiliated with any drug or medical device companies. We do not host advertisements nor do we accept advertising requests. We are here to help YOU, the consumer, become better educated and supported. You pay absolutely nothing for our help. It’s as simple as that.

Periscope Group is not owned by or operated on behalf of any attorney or law firm. We are not affiliated with any drug or medical device companies. We do not host advertisements nor do we accept advertising requests. We are here to help YOU, the consumer, become better educated and supported. You pay absolutely nothing for our help. It’s as simple as that.

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