Diabetes is a complicated condition to manage: learning what to eat, how to measure your blood sugar levels, and knowing the signs of neuropathy and diabetic ketoacidosis are just a few things to familiarize yourself with. Another important topic to understand concerns the medications that you take, how to take them, and what side effects/adverse effects to be aware of. If you’ve been prescribed Invokana, here are some common questions and answers that you should know about this type 2 medication.

4 Common Questions Patients Have About Invokana
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1. How Does Invokana Work?

Your kidneys filter glucose (sugar) from your blood and then returns it for your body to use as energy. Invokana alters this process by taking some of this glucose and instead of returning it to your blood, it causes you to urinate it out therefore bringing down your glucose levels. It prevents the sodium glucose co-transporter 2 from reabsorbing the glucose, so this type of medication is called a SGLT2 Inhibitor.

2. How Do I Take Invokana?

Invokana is a 100mg or 300mg once a day pill that can be taken with or without food.

3. Is There a Generic Version Available?

Invokana’s technical name is canagliflozin and currently there is no generic options on the market.

4. Are There Any Invokana Health Risks That I Should Know About?

There has been a lot of controversy surrounding Invokana and the FDA has published six alerts on this medication since it was approved for market back in March 2013. Here are the dangerous adverse effects that you should be aware of:

  • May 2015 – The FDA warns that there is an increased risk of ketoacidosis with use of Invokana. Ketoacidosis occurs when your blood sugar is too high for too long and acids build up in your blood. This can result in loss of consciousness, a coma, and potentially even death.
  • May 2016 and Updated May 2017 – The FDA warns that Invokana may increase the risk of leg and foot amputations. In clinical trials, it was found that patients taking Invokana were twice as likely to experience an amputation of the lower leg or foot as compared to those who took a placebo. Some doctors speculate that Invokana may cause the blood to thicken and pool in the foot increasing the risk for complications. Certain patients in the study even suffered from amputations in both limbs.
  • June 2016 – Patients taking Invokana could suffer from acute kidney injury which may require hospitalization and dialysis.
  • August 2018 – The FDA alerted the public that Invokana can cause serious genital infections called ecrotizing fasciitis of the perineum, and more commonly known as Fournier’s gangrene. “Fournier’s gangrene is an extremely rare but life-threatening bacterial infection of the tissue under the skin that surrounds muscles, nerves, fat, and blood vessels of the perineum,” explains the FDA announcement. “The bacteria usually get into the body through a cut or break in the skin, where they quickly spread and destroy the tissue they infect.”

As with any medication, it’s important to discuss the benefits and risks with your doctor. If you experienced any of the complications listed above – diabetic ketoacidosis, lower leg or foot amputation, kidney failure, or Fournier’s gangrene – contact Periscope Group at (800) 511-3838. Patients weren’t properly warned of these dangers and may be able to receive financial compensation. Call us today; we want to hear your story.


“What’s Invokana? 10 Things You Need to Know”. GoodRX. Accessed January 22, 2019. https://www.goodrx.com/blog/whats-invokana-10-things-you-need-to-know/
“What is Invokana?” Invokana.com. Accessed January 22, 2019. https://www.invokana.com/about-invokana/what-is-invokana
“Canagliflozin”. FDA MedlinePlus. Accessed January 22, 2019. https://medlineplus.gov/druginfo/meds/a613033.html
“Invokana FDA Alerts”. Drugs.com. Accessed January 22, 2019. https://www.drugs.com/fda-alerts/3465-16153.html
“What You Should Know About Diabetic Ketoacidosis”. WebMD. Accessed January 22, 2019. https://www.webmd.com/diabetes/ketoacidosis