By Christina Morales, Editor-in-Chief
Periscope News Group
September 7, 2018

Type 2 diabetes affects millions of people in the United States and many patients turn to prescription medications to help them manage their blood glucose levels. Two popular type 2 diabetes medications on the market are Invokana (canagliflozin) and Invokamet (a combination of Invokana and metformin HCI). These types of medications fall under a class of medicines called sodium-glucose cotransporter-2 (SGLT2) inhibitors. Just last month, the FDA published a new warning stating that SGLT2 inhibitors can cause serious infections in the genital area and may even cause amputations in men of the penis or testicles.

SGLT2 inhibitors entered the market in 2013 and worked in a new way (as opposed to traditional type 2 medications) by causing the kidneys to remove excess sugar from the body through the urine. However, this drug was never fully tested and by July 2017, the FDA announced that many were reporting that Invokana and Invokamet were linked to amputations of the toes, foot, or lower leg.

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This newest FDA report is based on an increase of adverse effects in patients experiencing Fournier’s gangrene, a condition that kills soft tissue in the genital area. This deadly bacterial infection enters the body through a cut or opening in the skin and attacks the tissue that surrounds muscles, nerves, fat, and blood vessels of the perineum (the area between the penis or vagina and rectum). Diabetics are more prone to this condition because their immune system is already compromised from having diabetes. Diabetics are also at an increased risk of amputation due to diabetic neuropathy – nerve damage that is associated with diabetes that cause cause sores and infections. If these wounds are left untreated, they could lead to amputation.

Up to 70% of those who are suffering from Fournier’s gangrene have diabetes and it most commonly occurs in men around the scrotum or penis. Treatment options may involve antibiotics, cleaning and removal of infected tissue, or oxygen therapy to prevent the bacteria from spreading. If left untreated, a doctor may have to remove the infected tissue which could include all or part of the penis and testicles. Symptoms can include pain, swelling, and/or a foul odor in the genital area.

If you took Invokana or Invokamet and were diagnosed with Fournier’s gangrene, you may be eligible for financial compensation. You weren’t warned of the risks associated with this dangerous medication and you likely have high medical bills and lost wages that are making life difficult for you. Contact Periscope Group today. We would love to hear your story.


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